RESEARCH
Boost NMR at High Magnetic Field
Nanosystems designed for molecular recognition can selectively bind small molecules. Using this property and a clever system design, we aim at enhancing the NMR signal of specific molecules in a mixture. The method will find application in chemosensing, sensoristics, and NMR on microfluidics chips.
Dynamics at the Solid-Liquid Interface
With an unconventional use of Dynamic Nuclear Polarization, we assess molecular dynamics at the solid-liquid interface by measuring macroscopic parameters. Proper optimization of this novel methodology can enable new experiments in the biology of membranes, catalysis, and material science.
Molecular Recognition for DNP
Nanosystems designed for molecular recognition can selectively bind small molecules. Using this property and a clever system design, we aim at enhancing the NMR signal of specific molecules in a mixture. The method will find application in chemosensing, sensoristics, and NMR on microfluidics chips.
HOW CAN YOU CONTRIBUTE
Spin dynamics of the electron-nuclear polarization transfer
The polarization transfer efficiency critically depends on the molecular motions that modulate the electron-nuclear hyperfine coupling. Numerical calculations can help in understanding the spin polarization mechanisms.
what Prediction of the DNP efficiency for a set of radicals and target molecules.
how Molecular dynamics and density functional theory simulations.
tech Simulation softwares; data processing methods.
EPR Spectroscopy at very high magnetic fields
Characterization of the EPR properties of organic radicals used as polarizing agents for DNP in liquids.
what Characterization of the frequency dependence and of the effect of solvent on the EPR properties of organic radicals.
how Development of protocols for sample preparation in oxigen-free atmosphere. EPR measurements at high magnetic fields and data analysis.
tech Basic wet lab methods; state-of-the-art 120-390 GHz heterodyne quasi-optical spectrometer; matlab simulations.
New polarizing agents for DNP-NMR
Polarizing agents other than nitroxide radicals have never been tested for DNP in liquid state at high magnetic fields.
what Assessment of the performance of BDPA, trityl, and galvinoxyl radicals as polarizing agents at 14.1 T.
how Quantitative DNP-NMR measurements at 14.1 T.
tech Basic wet lab methods; CW EPR at 9 GHz; DNP-NMR. instrument operating at 14.1 T.
